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1963年 Giordano C 首先用低蛋白饮食(LPD)加8种必需氨基酸(EAA)治疗慢性肾功能衰竭(CRF),不仅使尿毒症症状缓解,而且达到了正氮平衡。七十年代以后,EAA 疗法引起普遍重视,成为晚期肾脏疾病综合治疗中的重要
In 1963 Giordano C first treated chronic renal failure (CRF) with a low-protein diet (LPD) plus eight essential amino acids (EAA), not only to relieve uremic symptoms but also to achieve a positive nitrogen balance. After the seventies, EAA therapy has caused widespread concern and become important in the comprehensive treatment of advanced renal disease