雄黄量子点引起JEC细胞自噬的相关研究

来源 :2016年全国抗炎免疫药理学术会议 | 被引量 : 0次 | 上传用户：awind54335

【摘要】

：

目的:雄黄配伍中药或西药均能增强抗肿瘤药物的药效.但雄黄水溶性低,而雄黄量子点(Realgar Quantum Dots,RQDs)易溶,且有较强的抗肿瘤活性.本实验研究了RQDs抑制子宫内膜癌JEC细胞的增殖及与自噬的关系.方法:透射电镜观察RQDs作用于JEC细胞后自噬体的产生;共聚焦显微镜观察JEC细胞转染质粒p-EGFP-C3-LC3B后的荧光变化;Western Blot检测自噬相关蛋白

【作者】

：

刘正芸勾英肖冬焱刘杰王欢

【机构】

：

遵义医学院,医学与生物学研究中心;遵义医学院,基础药理省部共建教育部重点实验室,贵州遵义,563000

【出处】

：

2016年全国抗炎免疫药理学术会议

【发表日期】

：

2016年11期

【关键词】

：

雄黄量子点(RQDs) JEC细胞细胞自噬

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

Rac1 signaling regulates cigarette smoke-induced inflammation in the lung via the Erk1/2 MAPK and ST

Objective: Cigarette smoke (CS) is the major risk factor for the development of chronic obstructive pulmonary disease (COPD).It contains a variety of oxidative components that were implicated in the r

会议

Interleukin-6Interleukin-8cigarette smoke extractRaclpulmonary inflammation

Cigarette smoke-induced MMP-9 mediates epithelial-mesenchymal transition regulated by protein tyrosi

Objective: Cigarette smoke (CS), the major cause of chronic obstructive pulmonary disease (COPD) and lung cancer, contains a variety of oxidative components that were implicated in the regulation of S

会议

Dihydrotanshinone I Attenuates Atherosclerosis in ApoE-deficient Mice: Role of NOX4/NF-κB Mediated L

Dihydrotanshinone I (DHT) is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases.However, its role in atherosclerosis remains un

会议

Dihydrotanshinone ⅠLipopolysaccharideLOX-1ROSAtherosclerosis

Effect of total ginsenosides on oxidative damage of pulmonary fibrosis in mice

Objective: To observe the protective effect and the underlying mechanism of total ginsenosides on bleomycin-induced pulmonary fibrosis.

会议

total ginsenosidespulmonary fibrosisalpha smooth muscle actinoxidative damage

Icariin Ⅱ attenuates myocardial fibrosis by down-regulating TGF-β1/Smad2 signaling pathway in sponta

Objective: To investigate the effects of icariin Ⅱ (IRS) on myocardial fibrosis in spontaneously hypertensive rats (SHR), and to explore the mechanisms.Methods: 14-week-old male SHRs were randomly div

会议

Icariin ⅡSHRmyocardial fibrosisTGF-β1Smad2

Tetrahydroxystibene glucoside protects dopaminergic neurons against 6-OHDA-induced neurotoxicity via

Parkinsons disease (PD) is a neurodegenerative disease characterized by a slow and progressive loss of dopamine (DA) neurons in the substantia nigra (SN).Neuroinflammation, an important contributor to

会议

Tetrahydroxystibene glucosideParkinson's disease6-Hydroxydopaminemicrogl

Icariin inhibits migration and adhesion of THP-1 to HUVECs induced by TNF-α throughsuppression of th

CX3CL1 is closely related with vascular inflammatory diseases, upregulation of CX3CL1 byactivation of NF-κB signaling pathway promote migration and adhesion of inflammatory cells tovascular wall leadi

会议

IcariinTNF-αCX3CL1/CX3CR1NF-κBTHP-1HUVECs

Effects and mechanisms of icariin on migration and adhesion of THP-1 to HUVECs induced by TNF-α

Objective: To investigate the effects of icariin (ICA) on migration and adhesion of human acute monocytic leukemia cell line (THP-1) to human umbilical vein endothelial cells (HUVECs) induced by tumor

会议

IcariinTNF-αCX3CL1/CX3CR1NF-κBTHP-1HUVECs

核受体FXR的抗炎机制研究

法尼醇X受体(farnesoidXreceptor,FXR)是属于核受体超家族的一类配体激活型转录因子.FXR在胆汁酸、肥胖和糖类代谢的基因调控中具有重要作用[1].经研究发现抗炎作用也是FXR的一项重要的功能,下面对其抗炎机制的研究作简要综述:1..配体激活FXR后可以抑制核转录因子NF-kB引起的炎症因子的表达,证明了FXR在肝炎反应中起负调节作用[2].Ingrid T.G.W.Bijsma

会议

核受体抗炎FXR配体

二氢丹参酮Ⅰ改善ApoE基因敲除小鼠动脉粥样硬化作用及机制研究

背景:LOX-1是表达于内皮细胞膜上的ox-LDL的主要受体,在动脉粥样硬化(atherosclerosis,AS)发生、发展过程中起重要作用.二氢丹参酮Ⅰ (DHT)是传统中药丹参的脂溶性成分之一.本研究探讨其对LOX-1表达的调控及对AS的改善作用.

会议

DHT动脉粥样硬化LOX-1NF-κBNOX4

雄黄量子点引起JEC细胞自噬的相关研究

与本文相关的学术论文