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Objective To evaluate the feasibility of staging liver fibrosis with susceptibility weighted imaging(SWI)and analysis the correlationship between the SWI and the serum makers in animal models.Methods Forty-five New Zealand white rabbits with high fat diet developed experimental model with hepatic fibrosis,which were injected 50%carbon tetrachloride(CCl4)olive oil solution subcutaneously,while in the control group with normal diet were injected olive oil subcutaneously with same dose.Respectively in 2nd,4th,6th and 8th weeks,8-12 rabbits in experimental group and 2 rabbits in control group were performed SWI scan after drawing 5-8 ml of blood which had be done before anesthesia for serological tests.Then serial pathological section samples were obtained from whole liver after MRI.The images of SWI were observed and the mean of SWI signal intensity(SIL)and liver-to-muscle SI ratio(RL/M)of liver parenchyma were calculated.The correlation between the stage of hepatic fibrosis with SWI and and pathological stage,the value of serum markers were analyzed respectively.The diagnostic performance of SWI for staging hepatic fibrosis was analyzed with the ROC curve.Results The analysis showed a negative correlation between the hepatic fibrosis stage in pathology and the value of RL/M,SIL in SWI respectively(Table 1).The spearman correlation coefficient were-0.641(p<0.01)and-0.314(p=0.021)respectively.The ROC analysis showed that AUC of RL/M was higher than that of SIL except in mild liver fibrosis group(Table 2,3).There were positive correlations between hepatic fibrosis stage in pathology and the value of HA,IV-c,LN,ALT respectively(Table 4).There were good negative correlations between the serum makers and RL/M,SIL respectively(p<0.05).The correlation analysis showed the negative correlation between RL/M and the value of HA,PCⅢ,TC,TG,ALT and AST respectivly.Multiple regression showed linear relationship among RL/M,IV and TC.The regression equation was R=1.364+0.001IV-0.005TC.Conclusion SWI was an effective imaging method to reflect the stage of hepatic fibrosis in this study.RL/M had potential to be a noninvasive biomarker to stage and monitor hepatic fibrosis.