• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. RasGRF2 Promotes Migration and Invasion of Colorectal Cancer Cells by Modulating Expression of MMP9

RasGRF2 Promotes Migration and Invasion of Colorectal Cancer Cells by Modulating Expression of MMP9

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：yichunjekiyi
【摘 要】
：
Purpose: Ras-specific guanine nucleotide-releasing factor 2(RasGRF2)is a member of the guanine nucleotide exchange factors family which is expressed in a variety of tissues and cancer.However,the role
【作 者】
：
Jie Dai Peifen Lu Junjun Chen Lihong Yan Lijun Yang Litao Zhang Yahui Li Zhiming Kang Tao Yang 
【机 构】
：
Department of Biochemistry & Molecular Biology,Shanxi Medical University,Taiyuan 030001,Shanxi,China
【出 处】
：
中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议
【发表日期】
：
2018年10期
【关键词】
：
Colorectal Cancer ras Guanine Nucleotide Releasing Factor AKT1 Protein Kinase NF 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
　　Purpose: Ras-specific guanine nucleotide-releasing factor 2(RasGRF2)is a member of the guanine nucleotide exchange factors family which is expressed in a variety of tissues and cancer.However,the role of RasGRF2 in cancer is less reported,especially in colorectal cancer(CRC).Hence,the present study aimed to investigated the function of RasGRF2 and ways in which it affects tumor progression in CRC samples and cell lines.
其他文献
TBX3通过促进NANOG转录而促进肝癌肿瘤干细胞的生成和功能
肝癌中的肿瘤干细胞(hepatic cancer stem cells,HCSCs)是导致肝癌发生、发展和复发的关键因素,这里我们通过调节转录因子TBX3的表达,来研究TBX3对HCSCs产生和功能的影响、及其分子机制。我们发抑制和促进TBX3表达可分别导致CD133+HCSCs的水平明显下调和上调。微球形成试验显示抑制和促进TBX3导致CD133+HCSCs的微球形成能力明显下调和上调。
会议
肝癌肿瘤干细胞TBX3NANOG
Identification,Characterization and Functional Investigation of Circular RNAs in SVZ of Adult Rat Br
Adult neural stem cells(NSCs)are able to self-renew and generate new neural cells.Identifying regulators of NSCs is significant for the development of NSC-based therapies for neurodegenerative disease
会议
circular RNAneural stem cellsubventricular zoneRNA-seqmicroRNA
SLFN11抑制原型泡沫病毒PFV复制功能及机制初探
泡沫病毒(foamy virus,FV)是一类特殊的反转录病毒,能感染体外培养的细胞,引起细胞病变死亡,但其在体内并不引发任何病症,仅保持持续感染并伴随宿主终身,机体的免疫系统在此过程中发挥了重要作用.宿主限制性因子是指在病毒复制过程的某个特定步骤与病毒相互作用,从而阻断病毒复制的宿主蛋白.Schalfen(Slfn)家族蛋白可以抑制细胞增殖、调控造血细胞及T细胞分化等免疫应答活动,近年来发现其具
会议
泡沫病毒SLFN11
MRPL35 is upregulated in colorectal cancer and regulates colorectal cancer cell growth and apoptosis
Mitochondrial ribosome proteins(MRPs),which are encoded by the nuclear genomic DNA,are important for mitochondrialencoded protein synthesis and mitochondrial function.Emerging evidence suggests that s
会议
Mitochondrial ribosomal protein L35colorectal cancerproliferationapoptosis
GIPC2,a novel tumor suppressor gene in pheochromocytoma,activates the expression of p27 through NONO
GIPC2 is a member of the GIPC family which regulates various cellular processes,including proliferation,cytoplasmic division and migration.The expression level of GIPC2 changes in a variety of tumors.
会议
GIPC2pheochromocytomaInteraction proteinTumor suppressor
八肋游仆虫赖氨酰tRNA合成酶的表达纯化及活性分析
赖氨酰-tRNA合成酶(Lysyl-tRNA synthetase,LysRS)是蛋白质生物合成中的关键酶,能够催化赖氨酸和相应tRNA的氨酰化反应.除氨酰化作用外,LysRS还参与了转录调控、信号传导及免疫应答等多种生命活动.本研究对单细胞原生动物八肋游仆虫(Euplotes octocarinatus)的LysRS进行了研究,所得结果如下：生物信息学分析表明,八肋游仆虫具有两个LysRS基因(
会议
八肋游仆虫赖氨酰tRNA合成酶表达纯化活性分析
Co-targeting of CK2α and YBX1 triggers additive anti-proliferation and anti-migration effects in can
The PI3K/AKT pathway plays important roles in the pathogenesis and progression of cancers.Protein kinase CK2 alpha(CK2α),one isoform of the catalytic subunit of serine/threonine kinase CK2,has been in
会议
CK2αYBX1PI3K/AKT pathwayCancer
Copy number variations of MTHFSD gene across pig breeds and its association with litter size traits
Copy number variation(CNV)is a major proportion of genetic variation,which changes the gene structure and dosage and affects gene expression and function.To validate the presence and the function of C
会议
Analysis of alternative splicing events by RNA sequencing in the ovaries of Xiang pig at estrous and
会议
Linking sno-lncRNA and SPA lncRNAs to Prader-Willi syndrome
Prader-Willi syndrome(PWS)is a neuro-developmental genetic disorder characterized with obesity and hyperphagia.Most cases of PWS can be attributed to a large(5-6Mb)paternal deletion of chr15q11-q13,bu
会议
PWSsno-lncRNASPAAlternative splicingHypothalamic-like neurons