Purpose: To evaluate the value of 3D CT whole brain perfused volume (3D PBV) based on CT angiography (CTA) row data in hyperacute cerebral infarction.Methods: 35 patients with stroke in 3 hours performed no enhancement CT (NECT) and CTA scan.3D software Neuro PBV was utilizes to process the CTA row data and PBV of brain was obtained.MR examination was performed in 6 hours after CT scan.The ischemic lesion volume and quantity on 3D PBV and NECT were compared with MR-DWI.Results: In 35 patients,the number of infarct lesion detected by MRI,PBV,NECT was 40,38,16 respectively.The results of Kappa analysis between NECT and PBV with MR were -0.0128,0.7622.The result of Paired t-test for measurement of volume between PBV and MRI was t=7.249,P>0.05.The lesions’ which did not been detected by PBV volume were less than 4.5cm3 Conclusion: 3D PBV has the potential to assess the full extent of an ischemic stroke at an early stage,whereas PBV is limited to a relatively small volume.The 3D PBV technique requires no additional x-ray exposure and contrast medium injection,and can be performed in a short period of time.