【摘 要】
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Purpose: Stevens-Johnsonsyndrome(SJS) and toxic epidermal necrolysis (TEN) are rare but severe cutaneous adverse reactions (SCAR) caused by a certain number of medications including antiepileptic carb
【机 构】
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Institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical University,Key Lab
【出 处】
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第九次全国脑电图与癫痫诊治进展高级讲授班及学术研讨会
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Purpose: Stevens-Johnsonsyndrome(SJS) and toxic epidermal necrolysis (TEN) are rare but severe cutaneous adverse reactions (SCAR) caused by a certain number of medications including antiepileptic carbamazepine (CBZ) and lamotrigine (LTG).Although a strong association between CBZSJS/TEN and HLA-B* 1502 has been found in Han Chinese patients, the relationship between LTG induced-SJS/TEN and HLA-B* 1502 was uncertain.Our previous study indicated a potential association between HLA-A*2402 and CBZ-SJS/TEN.We thus investigated the involvement ofHLA-A, B alleles in LTG -SJS Han Chinese patients.
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