【摘 要】
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Background The association of folate metabolism and carcinogenesis has been investigated,but the results are conflicting.We performed a meta-analysis to examine the effect of the interaction of serum
【机 构】
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Department of Clinical Laboratory,Peking Union Medical College Hospital,Peking Union Medical College
【出 处】
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中华医学会第八次全国中青年检验医学学术会议
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Background The association of folate metabolism and carcinogenesis has been investigated,but the results are conflicting.We performed a meta-analysis to examine the effect of the interaction of serum levels of homocysteine (Hcy),folate,and vitamin B12 and 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphism on risk of cancer overall.Method Two reviewers independently searched for all published studies of Hcy and cancer in PubMed,EMBASE-MEDLINE and Chinese databases.Pooled results were reported as odds ratios (ORs) and mean differences and presented with 95 ％confidence intervals (95 ％CIs) and 2-sided probability values.
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