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Various MOAs at the Na+ channel Tonic voltage-dependent blockade Negative shift of voltage curve Slowing of recovery Negative shift of voltage curve Slowing of recovery Frequency-dependent blockade Targets and mechanisms of AEDs Seizure aggravation by AEDs Seizure aggravation by AEDs Absence aggravated by AEDs AEDs: spectrum of activity Efficacy according to seizure type Etiopathogenesis of absence epilepsy Neuroanatomical background