【摘 要】
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MicroRNAs serve important functions in numerous biological processes.Whether microRNAs also act on dendritic cell (DC) differentiation and function remains unclear.In this study, both conventional DCs
【机 构】
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Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu Province 215123,Peop
【出 处】
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中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
MicroRNAs serve important functions in numerous biological processes.Whether microRNAs also act on dendritic cell (DC) differentiation and function remains unclear.In this study, both conventional DCs (cDCs) and plasmacytoid DCs (pDCs) were increased in miR-34a overexpressing bone marrow chimeric and transgenic (TG) mice.Further experiments showed that miR-34a may inhibit the translation of WNT1 to promote preDC development into cDCs and pDCs without affecting the proliferation and apoptosis of DCs.
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