【摘 要】
：
Selective hyper-responsiveness of the interferon system in major depressive disorders and depression induced by interferon therapy.The role of the interferon (IFN)-system in the pathogenesis of major
【机 构】
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University Hospital of Essen Germany
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
Selective hyper-responsiveness of the interferon system in major depressive disorders and depression induced by interferon therapy.The role of the interferon (IFN)-system in the pathogenesis of major depressive disorders and depressive side effects that are induced by IFN-therapy is not well understood.Therefore,50 Caucasian patients with chronic hepatitis C were treated with standard combination therapy consisting of pegylated IFN-α2a and ribavirin.The transcriptional profile 12h before and 12h after the first injection of IFN-α was analyzed to identify genes which are differentially regulated in patients with or without IFN-induced depression.For validation,PBMC from 22 psychiatric patients hospitalized for a severe depressive episode (SDE) and 11 controls were cultivated in vitro with pegylated IFN-α2a.Furthermore,gene expression was analyzed in post mortem brain specimens from 29 individuals after suicidal and non-suicidal death,respectively.
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