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  5. MET/β-Catenin axis cooperates with ARF in castration resistant prostate cancer progression and drug

MET/β-Catenin axis cooperates with ARF in castration resistant prostate cancer progression and drug

来源 :第五届广州国际肿瘤学会议暨第一届中国抗癌协会肿瘤靶向治疗专业委员会年会 | 被引量 : 0次 | 上传用户：anewday4all
【摘 要】
：
MET(or c-MET)kinase signaling is aberrantly upregulated in many cancers and interacts with β-Catenin in cancer progression.We previously showed MET especially nuclear MET(nMET)triggers oncogenic signa
【作 者】
：
Yingqiu Xie Wenfu Lu Shenji Liu Qing Yang Nazgul Sakenova Zhenbang Chen 
【机 构】
：
Department of Biology,Nazarbayev University School of Science and Technology,Astana,010000,Republic
【出 处】
：
第五届广州国际肿瘤学会议暨第一届中国抗癌协会肿瘤靶向治疗专业委员会年会
【发表日期】
：
2016年11期
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　　MET(or c-MET)kinase signaling is aberrantly upregulated in many cancers and interacts with β-Catenin in cancer progression.We previously showed MET especially nuclear MET(nMET)triggers oncogenic signaling cascades to promote the recurrent growth of castration resistant prostate cancer(CRPC).Here we report that ARF is essential for the activation of MET signaling in prostate cancer(PCa).
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