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  5. Endophilin A2 is an Endogenous Inhibitor of Integrin β1 Activation regulate the Adhesion and Migrati

Endophilin A2 is an Endogenous Inhibitor of Integrin β1 Activation regulate the Adhesion and Migrati

来源 :The 6th China-Russia International Conference on Medicine(第六 | 被引量 : 0次 | 上传用户：irugi
【摘 要】
：
Aim: Integrins are transmembrane receptors composed of α and β subunits, which mediate cell-extracellular matrix adhesions.Regulation of integrin activity is fundamentally important during many physio
【作 者】
：
Qian-Qian Wu Ming-Ming Ma Yong-Bo Tang Xiao-Fei Lv Jie Liu Yong-Yuan Guan Jia-Guo Zhou 
【机 构】
：
Department of Pharmacology, Cardiac and Cerebrovascular Research Center, Zhongshan School of Medcine
【出 处】
：
The 6th China-Russia International Conference on Medicine(第六
【发表日期】
：
2014年3期
【关键词】
：
endophilin A2 integrin β1 adhesion endothelial cell 
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Aim: Integrins are transmembrane receptors composed of α and β subunits, which mediate cell-extracellular matrix adhesions.Regulation of integrin activity is fundamentally important during many physiological processes.The aim of this article is to investigate the role of Endophilin A2 in integrin β1 activation and its mechanism.Methodes and Results:FACS analysis of cells stained for surface levels of active or inactive integrin β1 showed that knockdown Endophilin A2 enhanced integrin β1 activation (p＜0.01, vs control siRNA,n=6).
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