To achieve the simultaneous capture of various target proteins,the multi-epitope templates imprinted particles were developed by phase inversion-based polyethersulfone(PES)self-assembly(Figure 1).[1] Herein,with the top three high-abundance proteins in the human plasma,serum albumin,immunoglobulin G and transferrin,as the target proteins,their N-terminal peptides were synthesized as the epitope templates.After the preorganization of three epitopes and PES in dimethylacetamide,the multi-epitope templates imprinted particles were formed in water through self-assembly,by which the simultaneous recognition of three target proteins in human plasma was achieved with high selectivity.Furthermore,the binding kinetics study proved that the adsorption mechanism in this imprinting system towards three epitope templates was same as that on the single-epitope imprinting polymer.[2] These results demonstrate that our proposed multi-epitope templates imprinting strategy might open a new era of artificial antibodies to achieve the recognition of various targets simultaneously.