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  5. Transplantation of cellular repressor of E1A-stimulated gene modified embryonic stem cells improves

Transplantation of cellular repressor of E1A-stimulated gene modified embryonic stem cells improves

来源 :第11届中国介入心脏病学大会 | 被引量 : 0次 | 上传用户：wj781228
【摘 要】
：
Background Cellular repressor of E1A-stimulated genes (CREG) is a mannose-6-phosphate-containing secreted glycoprotein of 220 amino acids.It has been proposed that CREG acts as a ligand that enhances
【作 者】
：
ZHANG Jian TIAN Xiao-xiang YAN Cheng-hui ZHANG Xiao-lin KANG Jian HAN Ya-ling 
【机 构】
：
Department of Cardiology,Institute of Cardiovascular Research of People's Liberation Army,Shenyang
【出 处】
：
第11届中国介入心脏病学大会
【发表日期】
：
2013年7期
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Background Cellular repressor of E1A-stimulated genes (CREG) is a mannose-6-phosphate-containing secreted glycoprotein of 220 amino acids.It has been proposed that CREG acts as a ligand that enhances differentiation and/or reduces cell proliferation.In humans, the potential therapeutic role of embryonic stem cells (ESCs) in ischemic heart disease is subject to intense investigation.Particularly, the contribution of ESCs to angiogenesis and cardiomyogenesis in myocardial ischemia is not well established.In our studies, we induced myocardial infarct (MI) in mouse model, and monitored the effects of CREG modified ESCs transplantation on cardiac function.
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