【摘 要】
：
目的：观察加味四君子汤对改善大鼠胃黏膜免疫功能的作用。方法：Wistar鼠，雄性，220g～330g,灌胃给药阿司匹林300mg/kg，5小时之后即可[1]，以胃粘膜出现溃疡为造模成功。将40只大鼠随机分为4 组，分别为空白对照组（等量生理盐水）、自然恢复组（等量生理盐水）、加味四君子汤组（1.5ml/100g/d，3d）和思密达组（0.6g/d/kg，5d）。给药完成后，采集标本，进行胃黏液中N
【机 构】
：
河南省医药科学研究院；河南郑州 450052 河南省医药科学研究院；河南郑州 450052 郑州大
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目的：观察加味四君子汤对改善大鼠胃黏膜免疫功能的作用。
方法：Wistar鼠，雄性，220g～330g,灌胃给药阿司匹林300mg/kg，5小时之后即可[1]，以胃粘膜出现溃疡为造模成功。将40只大鼠随机分为4 组，分别为空白对照组（等量生理盐水）、自然恢复组（等量生理盐水）、加味四君子汤组（1.5ml/100g/d，3d）和思密达组（0.6g/d/kg，5d）。给药完成后，采集标本，进行胃黏液中NOS含量的测定、血清中IL-1β和TN-Fα的测定。
结果：胃黏液中NOS2的含量从正常对照组的8.18μmol/L,上 升到造模组的8.94μmol/L，经加味四君子汤和思密达治疗后分别恢复到8.00μmol/L、8.30μmol/L.血清中的IL-1β从正常对照组的223pg/ml,到造模组的320pg/ml,治疗后分别恢复到232pg/ml、246 pg/ml.TNF-α 从正常对照组的22.2pg/ml,到造模组的42.3pg/ml,治疗后分别恢复到27.3pg/ml、30.6 pg/ml。
结论：加味四君子汤对阿司匹林造成的胃黏膜损伤有修复和改善胃黏膜屏障作用，对血清中IL-1β和TNF-α 细胞因子有调整作用。
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