Non-nucleoside reverse transcriptase inhibitors(NNRTIs)have received wide attention due to their unique antiviral potency,high specificity and low cytotoxicity[1].
Benzophenone derivatives(BPs),such as GW678248 and GW4511,have been reported as a class of HIV-1 NNRTIs with excellent potency against a broad panel of wild type and resistant mutant strains[1,2].
The bioluminescence imaging with firefly luciferin-luciferase system been widely used in various fields,which isnoninvasive,high sensitivity,visualization and real-time in detection.
Tumor hypoxia,the condition where tumor cells have been deprived of oxygen,is a characteristic of solid tumors1.Tumor hypoxia is in result of unlimited tumor growth,increased oxygen consumption,blood