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Comparative investigations of bone regeneration performance for calcium sulfate hemihydrate (CaSO41/2O;CSH) only and CSH with mineralized collagen are reported in this article.The mineralized collagen is the nanohydroxyapatite/collagen (nHAC).The investigations included biocompatibility in vitro and performance of bone repair in vivo.Quantitative and qualitative biocompatibility assays with bone stromal stem cells were performed.