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Scientific questions mentioned in this talk:HIV associated neurodegenerative disorders(HAND),HIV associated malignancy(HAM),Infecfion and cancer.How do HIV virions enter CNS and cause neuronal damage?HIV associated inflammation and Cancer microenvironment.Unintegrated HIV DNA in macrophages canrelease inflammator viral and host cellproducts, thus co-activating bystandernormal tissue cells. This inter-cellularcrosstalk generates a microenvironmentthat is relevant to cancer progression.