【摘 要】
:
Background:CD4+ T cell is acknowledged as a key factor in the initiation phase of liver ischemia/reperfusion injury (IRI).The purpose of the current study is to validate the effect of antecedent near-
【机 构】
:
Study of transplantation of organs of the Shanghai Changzheng Hospital
论文部分内容阅读
Background:CD4+ T cell is acknowledged as a key factor in the initiation phase of liver ischemia/reperfusion injury (IRI).The purpose of the current study is to validate the effect of antecedent near-term administration of antiCD25 monoclonal antibody (anti-CD25) PC61 on IR-induced liver injury and see whether this effect was mediated via modulation of CD4+ T cells.
其他文献
Objective:The protective effects of N-acetylcysteine (NAC) treatment have been demonstrated during ischemia reperfusion injury (IRI) in several organs,but its underlying mechanism has not been suffici
Objective:C/EBP Homologous Protein (CHOP) has been shown to play a key role in endoplasmic reticulum (ER) stress-mediated apoptosis.EROlα,a target of CHOP,is an important oxidizing enzyme to regulate
Background:It has been well proved that acute inflammatory response and hepatocellular apoptosis contributed to the pathogenesis of liver ischemia reperfusion (IR) injury.A vast amount of research has
Methods:Liver transplantation (LTx) using Sprague-Dawley rats (250g,male) was employed to access potential preservation methods.All rat donors were randomized into following groups:control group,conve
Objective:Despite the prominent role IL-23 plays in autoimmune diseases,neither its impact on ischemia reperfusion injury,nor its induction mechanism in inflamed tissues,has been defined.Endoplasmic r
Objective:Our aim was to investigate the relationship between the protection of CORM-2 and the overexpression of HO-1.Materials and Methods:The expression of HO-1 was evaluated in kidney after 1 hour
Objective:To investigate the role of mammalian target of rapamycin (mTOR) signaling in proliferation and function of memory T cells.Methods:The nave and memory T cells were then used to examine the ex
Objectives:Tumor differentiation is a behavioral index for hepatocellular carcinoma (HCC) and a prognostic factor for HCC in patients who undergo orthotopic liver transplantation (OLT).However,the mol
Background and Aim:Biliary tract obstruction is a common clinical problem.Duodenum is the major organ where intestinal glucose absorption takes place.However,the effect of biliary tract obstruction on
Intestinal ischemia reperfusion (I/R) injury is a pathophysiology involving both local tissue injury and remote organ dysfunction.Accumulating evidence confirmed that the infiltration of neutrophils i