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Background: Kaposis-sarcoma-associated herpesvirus (KSHV) is etiologically associated with Kaposis sarcoma (KS).In our previously studies, a few HIV-1 restriction factors, including APOBEC3G, were up-regulated in KS tissues than the adjacent normal tissues.(apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G (APOBEC3G) deaminate cytidine residues in the newly synthesized DNA negative strand, causing G-A hypermutation.