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The anaphase promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase playing essential functions in mitosis.It is conserved from yeast to human and relies on two adaptor proteins,Cdc20 and Cdh1,to bring in substrates.APCCdh1is thought to prevent premature S phase entry by limiting the accumulation of mitotic cyclins in G1 and to regulate processes unrelated to cell cycle.