【摘 要】
：
Significant unmet medical needs exist in autoimmtme diseases such as Inflammatory Bowel Diseases.We are developing a new drug originated from plant in China.HMPL-004 is an herbal mixture used to treat
【机 构】
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Hutchison MediPharma Limited China
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Significant unmet medical needs exist in autoimmtme diseases such as Inflammatory Bowel Diseases.We are developing a new drug originated from plant in China.HMPL-004 is an herbal mixture used to treat autoimmune diseases.An extract of the herb, HMPL-004, inhibits TNF-and IL-1β,and prevents colitis in animal models.The efficacy and safety of HMPL-004 in patients with mildto-moderate ulcerative colitis have been determined.A randomized, double-blind, multicentre, 12-week parallel group study was conducted using HMPL-004 in patients with mild-to-moderately active ulcerative colitis.Disease activity was assessed at baseline and every 2 weeks for clinical response, and at baseline and 8 weeks by colonoscopy.The data suggest that HMPL-004 is an efficacious alternative to mesalazine in ulcerative colitis.
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