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  5. The Nrde pathway mediates small RNA-directed histone H3 lysine 27 trimethylation in Caenorhabditis e

The Nrde pathway mediates small RNA-directed histone H3 lysine 27 trimethylation in Caenorhabditis e

来源 :第五届中国小核酸技术与应用学术会议 | 被引量 : 0次 | 上传用户：cctv2009_33894352
【摘 要】
：
　　Small RNA-mediated chromatin modifications have been widely studied in plants and S.pombe.However,direct evidence of small RNA-guided sequence-specific chro
【作 者】
：
Hui Mao Chengming Zhu Dandan Zong Chenchun Weng Xiangwei Yang Hui Huang Dun Liu Xuezhu Feng Shouhong Guang 
【机 构】
：
SchoolofLifeSciences,UniversityofScienceandTechnologyofChina,Hefei,Anhui230027,P.R.China
【出 处】
：
第五届中国小核酸技术与应用学术会议
【发表日期】
：
2015年9期
【关键词】
：
RNA interference H3K27 trimethylation Nrde 
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　　Small RNA-mediated chromatin modifications have been widely studied in plants and S.pombe.However,direct evidence of small RNA-guided sequence-specific chromatin alterations is scarce in animals.In C.elegans,the nuclear RNAi defective(Nrde)pathway functions to transport siRNA from the cytoplasm to the nucleus,modulate transcription elongation,induce histone H3 lysine 9(H3K9)trimethylation,and mediate transgenerational inheritance of RNAi.
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