Recently discovered intratumoral diffusion resistance,together with poor solubility and non-targeted distribution of chemotherapeutic drugs,has significantly impaired the performance of cancer treatments.By developing a well-designed droplet-confined/cryodesiccation-driven crystallization approach,we successfully prepared nanocrystallites of insoluble chemotherapeutic drug paclitaxel(PTX)in forms of nanodots(NDs,~10 nm)and nanoparticles(NPs,~70 nm)with considerably high drug loading capacity.