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The properties of nanoparticles, however, are not only dependent on their size and shape, but are also determined by surface modification.As a novel deep profile control agent, nanoscale water-soluble crosslinked polyacrylamide microsphere has better compatibility,sealing and oil property.To improve the salt tolerances and shearing resistance, hydrophobic monomer was introduced to inverse microemulsion polymerization, and hydrophobic-modified crosslinked polymer nanometer microspheres were obtained.