【摘 要】
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Genomic instability has been implicated in a causal role in carcinogenesis.Genomic instability in the form of polyploidy has been implicated in a causal rol
【机 构】
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UMASS Medical School USA
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Genomic instability has been implicated in a causal role in carcinogenesis.Genomic instability in the form of polyploidy has been implicated in a causal role in cervical carcinogenesis.Infection by specific types of HPVs is strongly associated with development of cervical cancer.The cancer-related HPV types encode oncogene E7 that induces polyploidy.We recently found that HPV-16 E7 induced endoreduplication, a process of successive rounds of host DNA replication without an intervening mitosis, in response to DNA damage in primary human keratinocytes (PHKs).Endoreduplication couId lead to polyploidy as well as gene amplification and DNA breaks.
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