Phosphorylation of CDK2 on Threonine 160Influences Silencing of Sex Chromosome During Male Meiosis

来源 :生殖与发育医学进展探索2014上海研究生学术论坛 | 被引量 : 0次 | 上传用户：borchifish

【摘要】

：

Background:In mammalian meiosis,the X and Y chromosomes are largely unsynapsed and transcriptionally silenced during the pachytene stage of meiotic prophase (meiotic sex chromosome inactivation),formi

【作者】

：

Lu Wang Wenjing Liu Weidong Zhao Gendi Song Guishuan Wang Xiaorong Wang Fei Sun

【机构】

：

Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences,University

【出处】

：

生殖与发育医学进展探索2014上海研究生学术论坛

【发表日期】

：

2014年5期

【关键词】

：

histone modifications kinases meiosis MSCI p-CDK239 spermatocyte X chromosome Y

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

The regulation of nitric oxide synthase isoform expression in mouse and human Fallopian tubes:potent

Objects:Nitric oxide (NO) is highly unstable and has a half-life of seconds in buffer solutions.It is synthesized by NO-synthase (NOS) which has been found to exist in the following three isoforms:neu

会议

nitric oxide synthasesteroid hormonesFallopian tubeectopic pregnancy

Estrogen promotes survival of human endometrial stromal cells via CXCL12/CXCR4 upregulation-mediated

Objects:Aberrant aufophagy has been suggested to play a role in endometriosis and thus to involved in apoptosis of endometrial stromal cells (ESCs).However,the potential mechanismsthat regulate autoph

会议

estrogenCXCL12endometriosisautophagyendometrial stromal cell

Changes of MDA,SOD and GSH-PX in premature ovarian insufficiency mice induced by Tripterygium glycos

Objects:To evaluate biochemical changes in vivo in premature ovarian insufficiency (POI) mice induced by Tripterygium glycosides (TG) and to explore the possible pathogenesis of POI induced byTG.

会议

premature ovarian insufficiencytripterygium glycosidesmalondialdehydesuperoxi

干细胞蛋白Piwil1在子宫内膜癌中通过诱导EMT增强癌细胞干性

目的：Piwil1在生物发育过程中维持干细胞的功能并且在许多肿瘤中发挥癌基因功能.本研究旨在探讨Piwil1在子宫内膜癌的发生发展中是否发挥重要作用.方法：使用免疫组化方法检测Piwil1在正常子宫内膜(44例)、不典型增生的子宫内膜(17例)及子宫内膜癌中(83例)的表达.分别使用Piwil1表达质粒和Piwil1干扰质粒建立Piwil1上调或下调的细胞稳转株.通过MTT、平板克隆实验、tran

会议

Piwil1子宫内膜癌干性

Expression and epigenetic regulation of angiogenesis-related factors during dormancy and the recurre

Background:The initiation of angiogenesis can mark the transition from tumor dormancy to active growth and recurrence.Mechanisms that regulate recurrence in human cancers are poorly understood,in part

会议

Ovarian cancerDormancyRecurrenceAngiogenesisMethylationHistone modification

子宫内膜癌微环境中IL-6和芳香化酶参与的正向反馈环路促进了肿瘤局部雌激素的合成

目的：肿瘤与其间质之间的相互作用在子宫内膜癌的原位雌激素合成中起着重要作用，但其机制至今未明。以往研究证实肿瘤间质细胞内芳香化酶的表达增高参与了此过程，但芳香化酶的具体调节因子还未有报道。本研究探讨了在这一过程中的具体调节因子和机制。

会议

子宫内膜癌肿瘤微环境芳香化酶IL-6共培养

睑裂狭小综合征小鼠模型鉴定研究

目的：睑裂狭小综合征(BPES)是一种以眼睑与颌面畸形和卵巢早衰为特征的遗传病，由转录因子FOXL2突变导致。目前对FOXL2如何影响面部发育仍了解不多，也缺乏详细描述的动物模型。本研究对一个新发现的Foxl2调控区突变小鼠进行鉴定，以建立新的BPES动物模型，并探索FOXL2对颌面部发育的影响和表达调控机理。方法：我们利用CT成像、组织学染色等方法对FOXL2上游160kb处PB插入突变纯合小鼠

会议

Foxl2睑裂狭小综合征piggyBac转座子长距离调控序列

Mutant p53 (p53-R248Q) functions as an oncogene in promoting type Ⅰ endometrial cancer by upregulati

Objects:This study is conducted to elucidate the oncogenic funcion of p53-R248Q correlated with REGy in type Ⅰ endometrial cancer.Methods:REGy and mutant p53 expression in EC specimens were examined b

会议

Endometrial cancermutant p53 (p53-R248Q)REGyproliferationmigrationinvasion

CaMKIV通过促进MVH和MIWI与KIF17b的结合维持拟染色小体的结构完整性

目的：了解上海社区20～85岁男性的生殖健康状况。方法：采用多阶段整群随机抽样法，自2013年11月至2014年1月在在上海市黄浦区，嘉定区，普陀区，浦东新区抽取了29个街道中共1521名符合入选条件的调查对象，调查其身高、体重、吸烟饮酒情况，采用老年男子症状问卷(AMS)、国际前列腺症状(IPSS)评分表、慢性前列腺炎症状评分表(NIHCPSI)、国际勃起功能指数-5(IIEF-5)表、早泄诊断

会议

生殖健康男性问卷调查社区

microRNA-383 impairs phosphorylation of H2AX by targeting PNUTS and inducing cell cycle arrest in te

Objects:To study the function of miR-383 in DNA damage during spermatogenesis.Methods:We explored the expression of miR-383 in testicular tissues of infertile patients by microRNA array and Q-RT.And i

会议

microRNA-383protein phosphatase 1regulatory subunit 10spermatogenesisDNA dam

Phosphorylation of CDK2 on Threonine 160Influences Silencing of Sex Chromosome During Male Meiosis

与本文相关的学术论文