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Background:Granulocytic sarcoma of breast (GS) is extremely rare.Case Report:We present an unusual case of a granulocytic sarcoma in a womans right breast,without obvious clinical symptoms and An incidentally found mass at the outer quadrants of the right breast.We misdiagnosed as fibroadenoma by Breast X-ray photography.Low echo mass with the possibility of malignancy diagnosed by the ultrasound examination and MRI diagnosis is lymphoma.At last,pathological examination showed granulocytic sarcoma.Conclusions:GS is lack of associated symptoms or sensitive diagnostic modalities and is usually misdiagnosed,therefore,immunohistochemical staining of myeloperoxidase is necessary for a definite diagnosis.