【摘 要】
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Objective: It is now widely accepted that mitochondrial calcium homeostasis and mitochondrial biogenesis plays a series of key roles in physiopathological processes of mitochondria,including energy me
【机 构】
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The Fourth Military Medical University
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Objective: It is now widely accepted that mitochondrial calcium homeostasis and mitochondrial biogenesis plays a series of key roles in physiopathological processes of mitochondria,including energy metabolism,reactive oxygen species(ROS)production and cell apoptosis.Mitochondrial Ca2+signaling is strongly dependent on the mitochondrial Ca2+uniporter(MCU)complex and Na+/Ca2+exchanger(NCLX).The enzymes participated in the process of mitochondrial biogenesis are widely regulated by the mitochondrial Ca2+homeostasis.However,the functional role of mitochondrial Ca2+homeostasis in mitochondrial biogenesis remains unclear.Here we aimed to study the roles of mitochondrial calcium in mitochondrial biogenesis and the underlying mechanism of mitochondrial calcium in promoting mitochondrial biogenesis.
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