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Background and object Apoptosis is a major form of cell death in cerebral ischemia/reperfusion (I/R) pathogenesis and may represent a target for treatment.Diosmin (DM), a micronized purified flavonoid drug, possesses an anti-apoptotic effect in the treatment of varicose veins and renal injury.However, the effect of DM in the acute phase of cerebral I/R is not clear.This study investigated DMs role in cerebral I/R and its potential mechanism.