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BACKGROUND: Mesenchymal stem cells (MSCs) play a central role in mediating cell and tissue damage.Erythropoietin (EPO) can stimulate the proliferation and protraction of marrow-derived mesenchymal stem cells (mMSCs) under the renal injury microenvironment.Recent researches showed micro-vesicles (MVs) from MSCs contribute to recovery of damaged kidney.In the present study, the role of EPO on the MV derived from MSC and further protective effect of chronic kidney disease were investigated.