【摘 要】
：
Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurologic disorder caused by ATTCT expansion in the ATXN10 gene.Previously we have presented da
论文部分内容阅读
Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurologic disorder caused by ATTCT expansion in the ATXN10 gene.Previously we have presented data that Ataxin-10, the gene product of ATXN10, is phosphorylated by Plk1 at S77 and T82, and participates in cytokinesis.Herein we further identify that Aurora B coimmunoprecipates with and phosphorylates Ataxin-10 at S12.
其他文献
TGF-β is a pleiotropic cytokine which transduces its signal mainly through cell membrane receptors and cytosolic Smad proteins.TGF-β signaling is delicately b
MicroRNAs (miRNAs) have been shown to be dysregulated in virus-related cancers; however, miRNA regulation of virus-related cancer development and progression re
从采集的土样中用逐步稀释划线法分离到了127个菌株,筛选到一株具有抗肿瘤细胞活性的芽胞杆菌.研究了该菌株的最适生长温度、耐盐性等生长生理特性;通过菌落形态、镜检观察,
微生物广泛分布于地球上的各个角落,它们对矿物质的沉积和形成有着密切的关系.目前,微生物的生物成矿机制研究日益受到人们的广泛关注.本研究运用DGGE和RFLP等分子生态学的方
本研究选取辽宁千山、哈尔滨滨江湿地、哈尔滨巨源湿地,银沙湾和哈尔滨市政府广场等地为土样采集地区,以地表以下5-10公分的腐殖土作为采集对象,共采集土壤样品3000份,利用温
蛴螬是鞘翅目金龟甲总科幼虫的总称,它栖居地下,为害隐蔽,已成为国内外公认的难防治的一类害虫.据调查显示,目前我国为害严重的蛴螬种类主要有暗黑鳃金龟(Holotrichiaparalle
CKIP-1 was first identified as an interactive protein of casein kinase 2a and was implicated in tumor cell proliferation, muscle cell differentiation, cell apop
Autophagy is activated to maintain cellular energy homeostasis in response to nutrient starvation.However, autophagy is not persistently activated, which is poo
Prostaglandin endoperoxide H synthases (PGHSs)-1 and-2, also known as cyclooxygenases (COXs)-1 and-2, convert arachidonic acid (AA; 20:4 ω-6) to prostaglandin
15-Deoxy-△12,14-prostaglandin J2(15d-PGJ2) has been known to display multifaceted cellular functions, including anti-inflammatory and cytoprotective effects.Ho