DNA sequence+shape kernel enables alignment-free modeling of transcription factor binding

来源 :上海交通大学 | 被引量 : 0次 | 上传用户：rookielv

【摘要】

：

Transcription factors(TFs)bind to specific DNA sequence motifs.Several lines of evidence suggest that TF-DNA binding is mediated in part by properties of the local DNA shape: the width of the minor gr

【作者】

：

Wenxiu Ma Remo Rohs William Stafford Noble

【机构】

：

Department of Statistics,University of California Riverside,Riverside,CA 92521,USA

【出处】

：

上海交通大学

【发表日期】

：

2016年4期

【关键词】

：

TF-DNA binding specificity high-throughput binding assays kernel methods support

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DNA sequence+shape kernel enables alignment-free modeling of transcription factor binding

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