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  5. Kv7/KCNQ/M-channels modulate the intrinsic excitability and synaptic responses of pyramidal neurons

Kv7/KCNQ/M-channels modulate the intrinsic excitability and synaptic responses of pyramidal neurons

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：durrenchen
【摘 要】
：
The prefrontal cortex(PFC)critical for cognition is implicated in neuropsychiatric diseases such as cognitive deficit,depression and schizophrenia.The voltage-activated Kv7/KCNQ/M-channel or M-current
【作 者】
：
KeWei Wang 
【机 构】
：
Department of Molecular and Cellular Pharmacology,Peking University School of PharmaceuticalSciences
【出 处】
：
2016年国际生理学学术大会
【发表日期】
：
2016年6期
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　　The prefrontal cortex(PFC)critical for cognition is implicated in neuropsychiatric diseases such as cognitive deficit,depression and schizophrenia.The voltage-activated Kv7/KCNQ/M-channel or M-current modulates neuronal excitability that defines the fundamental mechanism of the brain function.However,whether the M-current functions to regulate the excitability of PFC remains elusive.In this presentation,I will present the recodings of native M-current in brain slices that modulates intrinsic excitability and synaptic responses of PFC pyramidal neurons.
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