【摘 要】
：
As the advanced organelles found in eukaryotic cells,lysosomes are considered crucial regulators of cell homeostasis.The acidic microenvironment in the cytoplasm is provided by lysosomes,which are res
【机 构】
：
Ministry of Education Key Laboratory of Synthetic and Natural Functional Molecule Chemistry,College
【出 处】
：
中国化学会第十届全国化学生物学学术会议
论文部分内容阅读
As the advanced organelles found in eukaryotic cells,lysosomes are considered crucial regulators of cell homeostasis.The acidic microenvironment in the cytoplasm is provided by lysosomes,which are responsible for the more acidic lysosomal lumen of cancer cells.
其他文献
In the first part,we will introduce our recent work about the role of ribose G-quartets and how they affect the properties of G-quadruplex structures.[1] Thermal stability denaturation experiments rev
由富鸟嘌呤核酸序列形成的G-四链体是目前最为引人关注的一类核酸特殊二级结构.G-四链体/富G 单链之间,G-四链体/其他二级结构之间的动态转换在众多生命事件中起着关键调控作用.因此,G-四链体被认为是继双螺旋之后又一个重要的功能性结构.然而,基因组转录组中存在众多核酸二级结构,同时也存在众多富G 序列,特别是由不同富G 序列所形成的G-四链体,其结构相似,但变化规律、功能与相互作用对象却大不相同,
Autophagy is a dynamic catabolic process initiated by oxidative stress and proceeding with the formation of autophagosomes and their subsequent fusion with lysosomes.
Cellular functional biomolecules have been regarded as attractive targets for biomedical research,molecular diagnostics and disease therapy.Our recent efforts have been devoted to in situ analysis and
The hydroxyl radical(· OH)has been considered to be one of the most reactive oxygen species produced in biological systems,which can cause DNA,protein,and lipid oxidation.
微小核糖核酸(microRNA,miRNA)是细胞内源性的一类非编码小RNA 分子,可在转录后水平调控基因的表达,参与了众多生理以及病理过程,对细胞内miRNA 所参与的生物学过程的解析或者调控对于生物医学则具有重要的意义。
肿瘤标志物的发现是肿瘤研究和诊治的前沿方向。近年提出的利用肿瘤细胞筛选特异性核酸适配体，进而发现肿瘤标志物的方法具有好的应用前景。但目前只有极少数成功的例子，其中的瓶颈问题就在于位于细胞膜上的核酸适配体靶分子的纯化/鉴定。我们利用定量蛋白质组学的方法和手段，成功发展了一种可原位交联、可全程监控的通用型核酸适配体靶标鉴定方法。
In structure-based drug design,automated de novo design methods are helpful tools for lead discovery as well as lead optimization.In a previous study(J.Chem.Inf.Model.,2011,51,1474–1491),we reported a
Optical imaging of diseases represents a highly dynamic and multidisciplinary research area,and second near-infrared region(NIR-Ⅱ,1000–1700 nm)imaging is at the forefront of the research on optical im
Because of their potential advantage with high sensitivity,selectivity,and compatibility with living cells fluorescent probes are the method of choice for measurement of specific reactive species such