【摘 要】
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Objective: Bone cancer pain seriously affects the quality of life of cancer patients.Our previous study found that endogenous formaldehyde was produced by cancer cells metastasized into bone marrow an
【机 构】
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Neuroscience Research Institute and Department of Neurobiology, Peking University, Beijing 100191,Ch
【出 处】
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中华医学会疼痛学分会第十一届学术年会
论文部分内容阅读
Objective: Bone cancer pain seriously affects the quality of life of cancer patients.Our previous study found that endogenous formaldehyde was produced by cancer cells metastasized into bone marrow and played an important role in bone cancer pain.However, the mechanism of production of this endogenous formaldehyde by metastatic cancer cells was unknown in bone cancer pain rats.Lysine-specific demethylase 1 (LSD1) is one of the major enzymes catalyzing the production of the formaldehyde.This study aimed to investigate that LSD1 in the metastasized MRMT-1 breast cancer cells in bone marrow produced the endogenous formaldehyde in bone cancer pain rats.
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