【摘 要】
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Background Myocardial injury during percutaneous coronary intervention(PCI)occurs in 10-40％ of cases and is often characterized by a slight increase in the markers of myocardial necrosis, without symp
【机 构】
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Tianjin Chest Hospital
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Background Myocardial injury during percutaneous coronary intervention(PCI)occurs in 10-40％ of cases and is often characterized by a slight increase in the markers of myocardial necrosis, without symptoms, electrocardiographic changes or impairment of cardiac function.However, even small increases in creatine kinase (CK)-MB levels are an expression of a true and detectable infarction and may be associated with a higher follow-up mortality.It has been suggested that the main mechanism explaining the occurrence of myocardial necrosis during otherwise successful coronary intervention may be distal microembolization of plaque components, an enhanced inflammatory state or total plaque burden and/or instability.Different treatments have been proposed to prevent myocardial injury during coronary intervention, including nitrate infusion, intracoronary beta-blockers, adenosine and Ⅱb/Ⅱa inhibitors, but none of these(apart from the use of Ⅱb/Ⅲa inhibitors) have been routinely introduced into clinical practice.Therefore our study aimed to investigate the effects of different doses of atorvastatin combined with probucol on extent of myocardial injury in patients undergoing PCI and its possible mechanism.
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