赖氨酸单甲基化调节IRF4介导的转录活性及功能

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户：iamssisy

【摘要】

：

干扰素调节因子4(IRF4)通过转录调控细胞分化核心转录因子及分泌型细胞因子表达,从而介导体内多种天然免疫细胞如树突状细胞和巨噬细胞,辅助性T细胞如Th2, Th9,Th17,和调节性T细胞如FOXP3+Treg等不同细胞亚型的分化与功能。目前,IRF4在不同免疫细胞亚群中是如何行使其特定转录功能的分子机制尚不清楚。我们发现在TCR刺激条件下,CD4+T细胞中IRF4蛋白K123位点发生单甲基化,

【作者】

：

聂佳朱福香惠兆元单昭李丹 Andy Tsun 汪冽李斌

【机构】

：

中科院分子病毒及分子免疫重点实验室,分子免疫学课题组,中国科学院巴斯德研究所浙江大学免疫学研究所

【出处】

：

中国细胞生物学学会2015年全国学术大会

【发表日期】

：

2015年4期

【关键词】

：

Th2 IRF4 SUV39H1 甲基化

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赖氨酸单甲基化调节IRF4介导的转录活性及功能

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