【摘 要】
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Dysregulation of iron homeostasis is involved in the pathological process of Alzheimer’s disease (AD).We have recently reported that divalent metal transporter
【机 构】
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DepartmentofPathophysiology,ChinaMedicalUniversity,Shenyang110001
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Dysregulation of iron homeostasis is involved in the pathological process of Alzheimer’s disease (AD).We have recently reported that divalent metal transporter 1 (DMT1) is up-regulated in an AD transgenic mouse brain,on the contrary,the silencing of DMT1,which reduces cellular iron influx,results in inhibition of amyloidogenesis in vitro.The results suggest that DMT1 may be a potential target for AD therapy.In the present study,we tested the hypothesis that inhibition of DMT1 with ferristatin which can inhibit the activity of DMT1 could affect APP processing.Both human neuroblastoma SH-SY5Y neo cells and SH-SY5Y APPsw cells were pre-treated with ferristatin and then treated with ferrous sulfate (dissolved in ascorbic acid),and the effects of ferristatin on APP processing were examined.
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