【摘 要】
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Temporal lobe epilepsy(TLE)is the most common type of epilepsy and is often medically refractory.Here we report pharmaco-genetical approaches that allow cell-type specific inhibition of neuronal excit
【机 构】
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Department of Pharmacology,Key Laboratory of Medical Neurobiology of the Ministry of Health of China
【出 处】
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第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis
论文部分内容阅读
Temporal lobe epilepsy(TLE)is the most common type of epilepsy and is often medically refractory.Here we report pharmaco-genetical approaches that allow cell-type specific inhibition of neuronal excitability and control of TLE.Pharmaco-genetical activation of hippocampal parvalbumin neurons(a sub-type of GABAergic neurons)in seizure focus,using viral expression of the modified muscarinic receptor hM3Dq,attenuates both acute seizure model and chronic spontaneous epilepsy model with no obvious side effects.This anti-epileptic effect is mediated by GABAa receptor-mediated inhibition on pyramidal neurons.Meanwhile,directly pharmaco-genetical inactivation of pyramidal neurons,using viral expression of the modified muscarinic receptor hM4Di,produces similar anti-epileptic effect and further delays kindlinginduced epileptogenesis.These results indicate that pharmaco-genetical seizure attenuation may be a novel promising approach to treat refractory TLE with minimizing disruption of normal circuit function.
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