【摘 要】
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Objective: The purpose of this study is to examine expression of Vav3 and effect and mechanism of Vav3 gene to regulate inhibitor of apoptosis proteins in human gastric cancer cell line BGC823 is also
【机 构】
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The Fourth Affiliated Hospital, Hebei Medical University,Shijiazhuang 050011, China
【出 处】
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第十届全国胃癌学术会议暨第三届阳光长城肿瘤学术会议
论文部分内容阅读
Objective: The purpose of this study is to examine expression of Vav3 and effect and mechanism of Vav3 gene to regulate inhibitor of apoptosis proteins in human gastric cancer cell line BGC823 is also explored.Methods: The expression of Vav3 in gastric cancer tissues and cell lines were detected.Specific siRNA targeting Vav3 were designed, synthesized, and transfected into BGC823.The expression of Vav3 was detected by real-time quantitative PCR and western blot Cytoactive was measured with MTT assay Cell apoptosis rate were determined by flow cytometry (FCM).The expressions of Survivin, c-IAP1,c-IAP2, XIAP, Livin and Caspase-3 were also determined.
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