Process analytical technology is routinely used to monitor reactions; however,most monitoring methods require some type of calibration step to normalize the output to relate concentration versus time.1 Even then,it may not be readily apparent which species in the reaction matrix are responsible for a given change in analytical response.NMR overcomes these limitations as it inherently provides a quantitative signal response based on the number of nuclei,and it is the primary structural elucidation tool for small molecule characterization.