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Five major breast tumor subtypes including Basal-like, HER2+, Luminal A, Lumina B, and Normal-like were identified (Perou 2000) and validated (Hu 2006) using gene expression mieroarrays.Further analysis of combining microarray and qRT-PCR data stratified a PAM50 for breast cancer subtyping (Parker 2008).PAM50 contains 50 genes that can classify breast cancer into five subtypes.Nanostrings nCounter system has capability to count specific RNA molecules up to 800 genes in a multiplex format.