【摘 要】
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Objective To investigate whether prior use of atorvastatin reduces the frequency of pneumonia and whether it is related to inflammatory factors evolution in patients with acute ischemic stroke.Methods
【机 构】
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Department of Intensive Care Medicine,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong Universi
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Objective To investigate whether prior use of atorvastatin reduces the frequency of pneumonia and whether it is related to inflammatory factors evolution in patients with acute ischemic stroke.Methods Totally 492 patients with acute ischemic stroke and Glasgow Coma Scale≤8 from 3 teaching hospital were enrolled in this study.All the patients who were treated atorvastatin 20mg per night when admitted to the hospital were devided into prior atorvastatin use group(n=268) and control group(n=224).Pneumonia frequency, 30 days mortality and inflammatory factors (leukocyte, c-reactive protein, procalcitonin, proadrenomedullin, tumor necrosis factor-alpha,interleukin-6)were measured during intensive care unit stay.Adverse events related to statin treatment were also documented.
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