体外循环时不同动脉血氧分压对紫绀型先天性心脏病婴幼儿超氧化物歧化酶、丙二醛的影响

来源 :第五届上海国际新生儿医学论坛 | 被引量 : 0次 | 上传用户：qq1094795388

【摘要】

：

【作者】

：

黄灿农绍汉陈寄梅何少茹陈萍丁以群岑坚正许刚

【机构】

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广东省汕头市中心医院新生儿科广东省医学科学院新生儿科

【出处】

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第五届上海国际新生儿医学论坛

【发表日期】

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2015年9期

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目的对紫绀型先天性心脏病(CHD)婴幼儿体外循环(CPB)时动脉血氧分压(PaO2)与组织过氧化损伤的关系进行前瞻性研究.方法 2010年8月1日至2011年1月31日期间年龄0～3岁、脉搏血氧饱和度＜85％的发绀型CHD婴幼儿共45例,电脑软件随机分为三组:控制组1(G1组),控制组2(G2组)和非控制组(G3组),每组均为1 5例,在CPB过程中分别全程控制PaO2在80 ～ 120mmHg、120～200mmHg和200 ～ 400mmHg范围内.三组患儿的一般资料及可能相关的影响因素均基本一致(观察因素PaO2除外),于CPB开始前(T1)、CPB刚结束时(T2),以及CPB结束后3h(T3)、5h(T4)与24h(T5)分别抽取外周血并采用化学比色法测定超氧化物歧化酶(SOD)、丙二醛(MDA)的含量.

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体外循环时不同动脉血氧分压对紫绀型先天性心脏病婴幼儿超氧化物歧化酶、丙二醛的影响

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