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  5. TERT Promoter Mutations and Gene Amplification: Promoting TERT Expression in Merkel Cell Carcinoma

TERT Promoter Mutations and Gene Amplification: Promoting TERT Expression in Merkel Cell Carcinoma

来源 :2016第九届世界癌症大会 | 被引量 : 0次 | 上传用户：c1133186
【摘 要】
：
Telomerase activation through the induction of its catalytic component TERT is essential in carcinogenesis.The regulatory mechanism and clinical significance underlying cancer-specific TERT expression
【作 者】
：
Hong Xie Tiantian Liu Na Wang V Bj(o)rnhagen A H(o)(o)g C Larsson WO Lui D Xu 
【机 构】
：
Shandong University China
【出 处】
：
2016第九届世界癌症大会
【发表日期】
：
2016年7期
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　　Telomerase activation through the induction of its catalytic component TERT is essential in carcinogenesis.The regulatory mechanism and clinical significance underlying cancer-specific TERT expression have been extensively investigated in various human malignancies,but little is known about these in Merkel cell carcinoma (MCC),an aggressive neuroendocrine skin tumor.
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