【摘 要】
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Cytokine interleukin-6 (IL-6) has been showed to be an important mediator of neuroimmune responses.However,effects of IL-6 in the central nervous system (CN
【机 构】
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Department of Physiology, Faculty of Medicine, Nantong University, Nantong, 226001, China
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
Cytokine interleukin-6 (IL-6) has been showed to be an important mediator of neuroimmune responses.However,effects of IL-6 in the central nervous system (CNS) are quite complex and diverse,and mechanisms through which IL-6 influences neuronal functions are primarily unknown.In the present study,we explored protective effect of IL-6 that was chronically applied to cerebellar granule neurons (CGNs) in culture against neurodamage induced by N-methyl-D-aspartate (NMDA) and mechanisms involved in the neuroprotective effect of IL-6.The CGNs from infant rats of postnatal day 8 were chronically exposed to IL-6 for 8 days,and then NMDA was applied to the cultured CGNs for 30 min.CCK-8 assay,confocal laser-scanning microscope (CLSM),terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) method and Western blot were employed to measure neuronal vitality,dynamic changes of intracellular Ca2+ levels in the neurons,and neuronal apoptosis,respectively.
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