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目的：CD44+/CD24+/EPCAM+胰腺癌细胞被认为是胰腺癌干细胞。β-catenin是参与维持干细胞多能性的重要信号通路。我们的前期研究显示,PP2A抑制剂能够上调β-catenin的磷酸化水平,抑制β-catenin通路,进而抑制胰腺癌细胞的生长转移。
PP2A抑制剂通过抑制β-catenin信号通路削弱胰腺癌细胞多能性的机制研究
【摘 要】
：
目的：CD44+/CD24+/EPCAM+胰腺癌细胞被认为是胰腺癌干细胞。β-catenin是参与维持干细胞多能性的重要信号通路。我们的前期研究显示,PP2A抑制剂能够上调β-catenin的磷酸化水平,抑制β-catenin通路,进而抑制胰腺癌细胞的生长转移。
【机 构】
：
苏州 苏州大学附属第一医院肿瘤科
【出 处】
：
第十八届全国临床肿瘤学大会暨2015年CSCO学术年会
【发表日期】
：
2015年4期
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