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Summary This study aims to longitudinally assess the effect of oxytocin on bone and bone fat masses using micro-CT,in vivo magnetic resonance spectroscopy(MRS),and histopathological adipocyte quantification.Early in vivo oxytocin(OT)treatment to the osteoporosis(OP)rabbit model may reliably inhibit bone degeneration and reduce bone marrow fat accumulation by decreasing marrow adipocyte size and density.