【摘 要】
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The search for potent small molecule protein tyrosine phosphatase 1B inhibitors is a major thrust area in the management of type 2 diabetes mellitus and obesity.A useful and commonly adopted strategy
【出 处】
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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
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The search for potent small molecule protein tyrosine phosphatase 1B inhibitors is a major thrust area in the management of type 2 diabetes mellitus and obesity.A useful and commonly adopted strategy in the design of PTPlB inhibitors is to insert nonhydrolysable pTyr-mimetic groups that are able to replicate the interactions of pTyr residue with the active site of the enzyme onto different optimal templates [1,2].Based on the structure of the known pTyr-mimetic group(1)[3],we have designed 3-carboxyalkyl-4-oxo-2-thioxothiazolidin(2) as a biomimetic replacement for the phosphate group.
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